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 業績

主たる業績(英文誌のみ)   太字:教室員

 2017

  1. Ito Y, Katayama K, Nishibori Y, Akimoto Y, Kudo A, Kurayama R, Hada I, Takahashi S, Kimura T, Fukutomi T, Katada T, Suehiro J, Beltcheva O, Tryggvason K, Yan K: Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. Am J Physiol Renal Physiol. 2017 Feb 22:ajprenal.00305.2016. doi: 10.1152
  2. Takagi H, Nishibori Y, Katayama K, Katada T, Takahashi S, Kiuchi Z, Takahashi S, Kamei H, Kawakami H, Akimoto Y, Kudo A, Asanuma K, Takematsu H, Yan K: USP40 gene knockdown disrupts glomerular permeability in zebrafish. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F702-F715. doi: 10.1152
  3. Fukuhara D, Takiura T, Keino H, Okada AA, Yan K: Iatrogenic Cushing's Syndrome Due to Topical Ocular Glucocorticoid Treatment. Pediatrics. 2017 Jan 19. pii: e20161233. doi: 10.1542/peds.2016-1233. [Epub ahead of print] PMID: 28104732

 

 

 2016

  1. Keino H, Watanabe T, Taki W, Nakayama M, Nakamura T, Yan K, Okada AA. Clinical features of uveitis in children and adolescents at a tertiary referral centre in Tokyo. Br J Ophthalmol. 2016 Jun 22. pii: bjophthalmol-2015-308194. doi: 10.1136/bjophthalmol-2015-308194 
  2. Komatsu Y, Suzuki T, Tsurusaki Y, Miyake N, Matsumoto N, Yan K: TMEM67 mutations found in a case of Joubert syndrome with renal hypodysplasia. CEN Case Rep DOI 10.1007/s13730-0150210-1.
  3. Suzuki T, Miyake N, Tsurusaki Y, Okamoto N, Alkindy A, Inaba A, Sato M, Ito S, Muramatsu K, Kimura S, Ieda D, Saitoh S, Hiyane M, Suzumura H, Yagyu K, Shiraishi H, Nakajima M, Fueki N, Habata Y, Ueda Y, Komatsu Y, Yan K, Shimoda K, Shitara Y, Mizuno S, Ichinomiya K, Sameshima K, Tsuyusaki Y, Kurosawa K, Sakai Y, Haginoya K, Kobayashi Y, Yoshizawa C, Hisano M, Nakashima M, Saitsu H, Takeda S, Matsumoto N. Molecular genetic analysis of 30 families with Joubert syndrome. Clin Genet. 2016 Jul 19. doi: 10.1111/cge.12836. 
  4. *Gordon EJ, *Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E, Bentley K, Spurkland A, Claesson-Welsh L: The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci Signal. 9:ra72, 2016. *These authors contributed equally to this work.
  5. Kutsuna S, Yonetani S, Araki K, Izumiya H: A case of pediatric patient with acute enteritis due to CTX-M-15 extended-spectrum β-lactamase-producing Salmonella Blockley. Jpn J. Antibiot. 69(5):343-346,2016

 

 

 2014

  1. Oka M, Nozu K, Kaito H, Fu XJ, Nakanishi K, Hashimura Y, Morisada N, Yan K, Matsuo M, Yoshikawa N, Vorechovsky I, Iijima K. Natural history of genetically proven autosomal recessive Alport syndrome. Pediatr Nephrol. 2014 Sep;29(9):1535-44.
  2. Kimura T, Takahashi M, Yan K, Sakurai H: Expression of SLC2A9 Isoforms in the Kidney and Their Localization in Polarized Epithelial Cells. PLoS One. 2014 Jan 7;9(1):e84996. doi: 10.1371/journal.pone.0084996.
  3. Fumoto S, Hosoi K, Ohnsihi H, Hoshina H, Yan K, Saji H, Oka A: Chimerism of buccal membrane cells in a monochorionic dizygotic twin. Pediatrics 2014 Apr;133(4):e1097-100. doi: 10.1542.
  4. Miyai T, Aya K, Takaiwa M, Yan K, Sado Y, Tanaka H, Morishima T: Functional analysis of NPHS1 mutations in Japanese patients. Histol Histopathol 29:279-284, 2014. 

 

 

 2012

  1. Yan K, Ito N, Nakajo A, Kurayama R, Fukuhara D, Nishibori Y, Kudo A, Akimoto Y, Takenaka H: The struggle for energy in podocytes leads to nephrotic syndrome. Cell Cycle 11:1504-1511, 2012.
  2. Hara M, Yamagata K, Tomino Y, Saito A, Hirayama Y, Ogasawara S, Kurosawa H, Sekine S, Yan K: Urinary podocalyxin is an early marker for podocyte injury in patients with diabetes: establishment of a highly sensitive ELISA to detect urinary podocalyxin. Diabetologia 55:2913-2919, 2012.

 

 

 2011

  1. Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Lab Invest 81:992-1006, 2011.  
  2. Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, Asanuma K, Sai Y, Miyamoto KI, Takenaka H, Yan K: mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Lab Invest 91:1584-1595, 2011. 
  3. Sekiguchi S, Suzuki A, Asano S, Nishiwaki-Yasuda K, Shibata M, Nagao S, Yamamoto N, Matsuyama M, Sato Y, Yan K, Yaoita E, Itoh M: Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter. Am J Physiol Renal Physiol 300:F848-856, 2011. 

 

 

 2010

  1. Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S: Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant 25:2530-2537, 2010.
  2. Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H: Human sodium-phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem 285:35123-35132, 2010.

 

 

 2009

  1. Shimizu M, Khoshnoodi J, Akimoto Y, Kawakami H, Hirano H, Higashihara E, Hosoyamada M, Sekine Y, Kurayama R, Kurayama H, Jyo K, Hirabayashi J, Kasai K, Tryggvason K, Ito N, Yan K: Expression of galectin-1, as a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. Lab Invest 89:178-195, 2009. 
  2. Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdor Å, Tryggvason K, Yan K: Amino acid transporter LAT3 is required for podocyte development and function. J Am Soc Nephrol 20:1586-1596, 2009. 
  3. Aya K, Shimizu J, Ohtomo Y, Satomura K, Suzuki H, Yan K, Sado Y, Morishima T, Tanaka H: NPHS1 gene mutation in Japanese patients with congenital nephrotic syndrome. Nephrol Dial Transplant 24:2411-2414, 2009.

 

 

 1998~2008

  1. Saito H, Takahashi S, Nagata M, Tsuchiya T, Mugishima H, Yan K, Kondo Y, Matsuyama T, Sekine T, Igarashi T: Re-evaluation of glomerular charge selective protein-sieving function. Pediatr Nephrol 24:609-612, 2008.
  2. Fukuhara D, Kanai Y, Chairoungdua A, Babu E, Bessho F, Kawano T, Akimoto Y, Endou H, Yan K: Protein Characterization of Na+-Independent System L Amino Acid Transporter 3 in Mice: A potential role in supply of branched-chain amino acids under nutrient starvation. Am J Pathol 170:888-898, 2007. 
  3. Nakajo A, Khoshnoodi J, Takenaka H, Hagiwara E, Watanabe T, Kawakami H, Bessho F, Takahashi S, Swiatecka-Urban A, Tryggvason K, Yan K: Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. J Am Soc Nephrol 18: 2554-2564, 2007. 
  4. Waragai A, Yamashita H, Hosoi K, Hoshina H, Noda E, Yan K, Kawano T: High-frequency oscillation (HFO) prevents activation of NF-kappaB found with conventional mechanical ventilation (CMV) in surfactant-depleted rabbit lung. Pediatr Pulmonol 42:440-445, 2007.
  5. Takahashi S, Watanabe S, Wada N, Murakami H, Funaki S, Yan K, Kondo Y, Harada K, Nagata M: Charge selective function in childhood glomerular diseases. Pediatr Res 59:336-340, 2006.
  6. Fujii Y, Khoshnoodi J, Takenaka H, Hosoyamada M, Nakajo A, Bessho F, Kudo A, Takahashi S, Arimura Y, Yamada A, Nagasawa T, Ruotsalainen V, Tryggvason K, Lee AS, Yan K: The effect of dexamethasone on defective nephrin transport caused by ER stress: A potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases. Kidney Int 69:1350-1359, 2006. 
  7. Hosoyamada M, Yan K, Nishibori Y, Takiue Y, Kudo A, Kawakami H, Shibasaki T, Endou H: Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis. J Pharmacol Sci 97:234-241, 2005.
  8. Liu XL, Kilpelainen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, Pikkarainen T, Yan K, Jonsson AP, Tryggvason K: Characterization of the interactions of the nephrin intracellular domain. FEBS J 272:228-243, 2005.
  9. Liu XL, Done SC, Yan K, Kilpelainen P, Pikkarainen T, Tryggvason K: Defective trafficking of nephrin missense mutants rescued by a chemical chaperone. J Am Soc Nephrol 15:1731-1738, 2004.
  10. Nishibori Y, Liu L, Hosoyamada M, Endou H, Kudo A, Takenaka H, Higashihara E, Bessho F, Takahashi S, Kershaw D, Ruotsalainen V, Tryggvason K, Khoshnoodi J, Yan K: Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane. Kidney Int 66:1755-1765, 2004. 
  11. Kanemoto K, Takahashi S, Shu Y, Usui J, Tomari S, Yan K, Hamazaki Y, Nagata M: Variable expression of podocyte-related markers in the glomeruloid bodies in Wilms tumor. Pathol Int 53:596-601, 2003.
  12. Yan K, Khoshnoodi J, Ruotsalainen V, Tryggvason K: N-linked glycosylation is critical for the plasma membrane localization of nephrin. J Am Soc Nephrol 13:1385-1389, 2002.
  13. Kataoka S, Kudo A, Hirano H, Kawakami H, Kawano T, Higashihara E, Tanaka H, Delarue F, Sraer JD, Mune T, Krozowski ZS, Yan K: 11beta-hydroxysteroid dehydrogenase type 2 is expressed in the human kidney glomerulus. J Clin Endocrinol Metab 87:877-882, 2002. 
  14. Nakajima N, Sekine T, Cha SH, Tojo A, Hosoyamada M, Kanai Y, Yan K, Awa S, Endou H: Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int 57:1608-1616, 2000.
  15. Yan K, Kudo A, Hirano H, Watanabe T, Tasaka T, Kataoka S, Nakajima N, Nishibori Y, Shibata T, Kohsaka T, Higashihara E, Tanaka H, Watanabe H, Nagasawa T, Awa S: Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Kidney Int 56:65-73, 1999.
  16. Yan K, Nakahara K, Awa S, Nishibori Y, Nakajima N, Kataoka S, Maeda M, Watanabe T, Matsushima S, Watanabe N: The increase of memory T cell subsets in children with idiopathic nephrotic syndrome. Nephron 79:274-278, 1998.
  17. Yan K, Nakamura Y, Watanabe N, Kawato H, Fujimiya Y, Kohsaka T: Regulation of C3 production by interferon-gamma from peripheral blood T cells in patients with membranoproliferative glomerulonephritis and poststreptococcal acute glomerulonephritis. Nephron 72:623- 628, 1996.